NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000968
CAS NUMBER: 108-24-7
BASE CHEMICAL NAME: ACETICANHYDRIDE
PRIMARY NAME: ACETIC ANHYDRIDE
CHEMICAL FORMULA: C4H6O3
STRUCTURAL FORMULA:
WLN: 1V0V1
SYNONYMS:
ACETIC ACID, ANHYDRIDE (9CI)
ACETIC ANHYDRIDE (DOT)
ACETIC OXIDE
ACETYL ANHYDRIDE
ACETYL ETHER
ACETYL OXIDE
ETHANOIC ANHYDRATE
ETHANOIC ANHYDRIDE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: Colorless, mobile liquid
MOLECULAR WEIGHT: 102.09
SPECIFIC GRAVITY: 1.0830 @ 20/20
DENSITY: 1.08 g/mL
MP (DEG C): -73.1 C
BP (DEG C): 139.55 C
SOLUBILITIES:
WATER : Soluble in cold (>=10mg/ml); Decomposes in hot
DMSO : Not available
95% ETHANOL : Very soluble (>=10mg/ml)
METHANOL : Not available
ACETONE : Not available
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Soluble
Acetic acid: Very soluble
Ethyl acetate: Very soluble
ETHER : Very soluble
BENZENE: Soluble
VOLATILITY : Vapor Pressure: 10 mm @36 C, Vapor Density: 3.52
FLAMMABILITY(FLASH POINT):
The flash point for this chemical is 49.4 C (121 F); it is combustible.
Fires involving this compound should be controlled with a dry chemical, carbon
dioxide or halon extinguisher. The autoignition temperature is 385 C (725 F).
UEL: 10.3% LEL: 2.9%
REACTIVITY:
This compound reacts vigorously with oxidizing materials. Violent reactions
will occur on contact with water or steam and a variety of other organic and
inorganic compounds.
STABILITY:
This compound decomposes readily in the presence of moisture.
OTHER PHYSICAL DATA:
Strongly refractive liquid
TOXICITY
NIOSH REGISTRY NUMBER: AK1925000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1780 mg/kg
LCLo ihl rat 1000 ppm/4H
LD50 skn rbt 4000 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: MOD via oral, dermal and inhalation routes.
CARCINOGENICITY: Not available
MUTATION DATA: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 5 ppm [610]
Final Limit: Ceiling limit 5 ppm [610]
ACGIH: TLV-Ceiling Limit 5 ppm [610]
NIOSH Criteria Document:
NFPA Hazard Rating: Health (H): 2
Flammability (F): 2
Reactivity (R): 1
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R1: Materials which are normally stable but which may become unstable at
elevated temperatures and pressures or which may react with water with
some release of energy but not violently (see NFPA for details).
NFPA possible hazard in use of water
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 10 mg/24H MLD
skn-rbt 540 mg open MLD
eye-rbt 250 ug SEV
Status: "NIOSH Manual of Analytical Methods", Vol. 3, S170
Reported in EPA TSCA Inventory, 1980
EPA TSCA 8(a) Preliminary Assessment Information Proposed Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Acetic anhydride
UN/ID NUMBER: UN1715
HAZARD CLASS: 8 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Corrosive
PACKAGING: PASSENGER: PKG. INSTR.: 809, Y809 MAXIMUM QUANTITY: 1 L, 0.5 L
CARGO : PKG. INSTR.: 813 MAXIMUM QUANTITY: 30 L
SPECIAL PROVISIONS: None
USES:
Used in manufacture of acetyl compounds and cellulose acetates. Also as
acetualizer and solvent in examining wool fat, glycerol, fatty and volatile
oils and resins. Widely used in organic syntheses as dehydrating agent in
nitrations, sulfonations and other reactions where removal of water is
necessary.
COMMENTS: UN 1715 Air/Rail: Passenger-1 qt limit; cargo-1 gal limit.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is highly toxic by inhalation. Upon exposure you may expect
eye irritation and lacrimation and severe irritation of skin and mucous
membranes characterized by burning in the nose and throat. If ingested,
this compound will lead to abdominal pain, nausea and vomiting. This chemical
also emits highly toxic fumes when heated to decomposition.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS: P
The following gloves show the best resistance based on permeation
testing. It is recommended that two different glove types be used for
best protection. However, if this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, remove them at once.
SUGGESTED GLOVES: Butyl rubber, Neoprene (to 200 min.)
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this container from damage and moisture and store it
under refrigerated temperatures less than 5 degrees centigrade.
SPILLS AND LEAKAGE:
If you spill this chemical, use absorbent paper to pick up all liquid
spill material. Your contaminated clothing and absorbent paper should be
sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all
contaminated surfaces with alcohol followed by washing with a strong soap and
water solution. Do not reenter the contaminated area until the Safety Officer
(or other responsible person) has verified that the area has been properly
cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
This compound will cause irritation and corrosion of eyes, skin and mucous
membranes; cough and burning in the nose and throat; and nausea, vomiting and
abdominal pain if ingested.
FIREFIGHTING: Not available
SOURCES
SOURCES:
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemicals. Aldrich Chemical Co., Inc. Milwaukee, WI.
1980. pp. 5, no.11,004-3.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. pp. 720, no.10.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Proctor, N.H. and J.P. Hughes. Chemical Hazards of the Workplace.
J.B. Lippincott. Philadelphia. 1978. pp. 81.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 9th Ed.
Van Nostrand Reinhold. New York. 1977. pp. 6.
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. pp. 3.
Sax, N.I. Dangerous Properties of Industrial Materials. 4th Ed.
Van Nostrand Reinhold. New York. 1975. pp. 333.
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. pp. 7, no.44.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 60th Ed. CRC Press, Inc. Boca Raton, FL.
1982. pp. C-86, no.a172.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic
Effects of Chemical Substances. DHEW (NIOSH) Publication
No. 79-100. National Institute for Occupational Safety
and Health. Cincinnati, OH. 1979. AK19250000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 42.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Not listed.
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