NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000103
CAS NUMBER: 107-21-1
BASE CHEMICAL NAME: ETHYLENEGLYCOL
PRIMARY NAME: ETHYLENE GLYCOL
CHEMICAL FORMULA: C2H6O2
STRUCTURAL FORMULA: HOCH2CH2OH
WLN: Q2Q
SYNONYMS:
ETHANE-1,2-DIOL
1,2-DIHYDROXYETHANE
1,2-ETHANDIOL
1,2-ETHANEDIOL
ETHYLENE ALCOHOL
ETHYLENE DIHYDRATE
GLYCOL
GLYCOL ALCOHOL
LUTROL-9
MACROGOL 400 BPC
M.E.G.
MONOETHYLENE GLYCOL
TESCOL
NORKOOL
DOWTHERM SR 1
UCAR 17
NCI-C00920
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear, colorless, viscous liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 62.07
SPECIFIC GRAVITY: 1.1135 @ 20/4 C [033]
DENSITY: 1.1155 g/mL @ 20 C [062]
MP (DEG C): -13 C [033,043,205,269]
BP (DEG C): 197.6 C [033,071,205]
SOLUBILITIES:
WATER : >=100 mg/mL @ 17.5 C (RAD)
DMSO : >=100 mg/mL @ 17.5 C (RAD)
95% ETHANOL : >=100 mg/mL @ 17.5 C (RAD)
METHANOL : Soluble [029]
ACETONE : >=100 mg/mL @ 17.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [017,062,205]
Lower aliphatic alcohols: Miscible [033,051,430]
Glycerol: Miscible [033,051,205]
Acetic acid: Miscible [029,033,051,205]
Aldehydes: Miscible [033,051,430]
Pyridine and similar coal tar bases: Miscible [029,033,051,205]
Chlorinated hydrocarbons: Practically insoluble [033]
Petroleum ether: Practically insoluble [033]
Carbon tetrachloride: Insoluble [029]
Chloroform: Insoluble [029,205]
Ether: 1 in 200 [033]
Benzene and its homologs: Practically insoluble [033]
Oils: Practically insoluble [033]
Ketones: Miscible [033,051,430]
Carbon disulfide: Insoluble [029]
VOLATILITY:
Vapor pressure: 0.06 mm Hg @ 20 C [058,430]; 1 mm Hg @ 53.0 C [038]
Vapor density : 2.14 [043,051,055]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 111 C (232 F) [043,058,371,451].
It is combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher. A water spray may
also be used [043,058,451]. The autoignition temperature of this compound
is 400 C (752 F) [043,051].
UEL: Not available LEL: 3.2% [047,051,058,371]
REACTIVITY:
This chemical is incompatible with oxidizers, chromium trioxide, oleum,
chlorosulfonic acid, sulfuric acid, HClO4, phosphorous pentasulfide, potassium
permanganate and sodium peroxide. Mixtures with ammonium dichromate, silver
chlorate, sodium chlorite and uranyl nitrate ignite when heated to 100 C.
Aqueous solutions may ignite silvered copper wires which have applied D.C.
voltage [043].
STABILITY:
This chemical is very hygroscopic [033,043,062,275].
OTHER PHYSICAL DATA:
Specific gravity: 1.113 @ 25/25 C [043,051,269]; 1.1274 @ 0/4 C [033]
Specific gravity: 1.1065 @ 30/4 C; 1.1204 @ 10/4 C [033]; 1.11 @ 25/4 C [430]
Boiling point: 93 C @ 13 mm Hg [017]; 140 C @ 97 mm Hg; 100 C @ 18 mm Hg [033]
Boiling point: 70 C @ 3.0 mm Hg; 20 C @ 0.06 mm Hg [033]
Vapor pressure: 5 mm Hg @ 79.7 C; 10 mm Hg @ 92.1 C; 20 mm Hg @ 105.8 C [038]
Vapor pressure: 40 mm Hg @ 120 C; 760 mm Hg @ 197.3 C [038]
Odorless [062,346,430]
Viscosity: 26 centipoise @ 15 C; 21 centipoise @ 20 C [033]
Viscosity: 17.3 centipoise @ 25 C [033]
Refractive index: 1.43063 @ 25 C; 1.43312 @ 15 C [033]
Refractive index: 1.4318 @ 20 C [017,047,205]
Sweet taste [029,033,036,062]
Dielectric constant: 38.66 esu @ 20 C and 150 m wavelength [033]
Dipole moment: 2.20 [033]
Specific heat: 0.561 cal/g/C @ 20 C [033]
Heat of formation: -108.1 kcal/mol [033]
Heat of fusion: 44.7 cal/g [033]
Heat of vaporization: 191 cal/g [033]
Heat of solution: -6.5 cal/g @ 17 C (when 37 parts are mixed with 63 parts
water (w/w)) [033]
Surface tension: 48.4 dynes/cm @ 20 C [033]
log P octanol: -1.93 [055]
Evaporation rate (butyl acetate=1): <0.01 [058]
Absorbs twice its weight of water at 100% relative humidity [033]
TOXICITY
NIOSH REGISTRY NUMBER: KW2975000
TOXICITY:
typ. dose mode specie amount units other
TDLo orl chd 5500 mg/kg
LDLo orl hmn 786 mg/kg
TCLo ihl hmn 10000 mg/m3
LDLo unr man 1637 mg/kg
LD50 orl rat 4700 mg/kg
LD50 ipr rat 5010 mg/kg
LD50 scu rat 2800 mg/kg
LD50 ivn rat 3260 mg/kg
LDLo ims rat 3300 mg/kg
LD50 orl mus 7500 mg/kg
LD50 ipr mus 5614 mg/kg
LDLo scu mus 2700 mg/kg
LD50 ivn mus 3000 mg/kg
LD50 orl cat 1650 mg/kg
LDLo scu cat 2000 mg/kg
LD50 skn rbt 9530 mg/kg
LDLo ipr rbt 1000 mg/kg
LDLo ivn rbt 5 gm/kg
LDLo ims rbt 5500 mg/kg
LD50 orl gpg 6610 mg/kg
LDLo scu gpg 5000 mg/kg
LDLo orl hmn 398 mg/kg
LD50 orl dog 5500 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Human poison by ingestion. Moderately toxic to humans by an unspecified
route. Moderately toxic experimentally by ingestion, subcutaneous,
intravenous and intramuscular routes. Mildly toxic by skin contact.
A suspected carcinogen. An experimental teratogen. Human mutagenic
data.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies; on test (two year studies), July 1989
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: See RTECS printout for data
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89)
Final Limit: Ceiling Limit 50 ppm [015,545,610]
ACGIH: Ceiling Limit 50 ppm (vapor) [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 1
Flammability (F): 1
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rat 12 mg/m3/3D
eye-rbt 100 mg/1H MLD
eye-rbt 1440 mg/6H MOD
skn-rbt 555 mg open MLD
eye-rbt 12 mg/m3/3D
eye-rbt 500 mg/24H MLD
Review: Toxicology Review
Status: EPA TSCA Chemical Inventory, 1986
NIOSH Analytical Methods: see Ethylene Glycol, 5500
EPA Genetox Program 1988, Negative: Cell transform.-SA7/SHE; N crassa-
aneuploidy
EPA Genetox Program 1988, Negative: Histidine reversion-Ames test
EPA Genetox Program 1988, Inconclusive: D melanogaster-whole sex
chrom. loss
EPA Genetox Program 1988, Inconclusive: D melanogaster-nondisjunction
EPA TSCA Section 8(e) Status Report 8EHQ-0485-0552
EPA TSCA Test Submission (TSCATS) Data Base, January 1990
Human lethal dose: 1.4 mL/kg or 100 mL [033,043,051,430]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
This compound is used in antifreeze, in hydraulic brake fluids, as an
industrial humectant, as an ingredient of electrolytic condensers, as a solvent
in the paint and plastics industries, in the formulation of printers inks,
stamp pad inks and ball point pen inks, as a softening agent for cellophane and
as a stabilizer for soybean foam used to extinguish oil and gasoline fires.
It is used in the synthesis of safety explosives, glyoxal, unsaturated ester-
type alkyd resins, plasticizers, elastomers, synthetic fibers and synthetic
waxes. It is also used in asphalt emulsion, as a heat transfer agent and as an
ingredient for deicing airport runways.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion [033]. It may be readily absorbed
through the skin [058,269]. When heated to decomposition it emits acrid
smoke, irritating fumes and toxic fumes of carbon monoxide, carbon dioxide
and unidentified organic compounds [043,058].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PVC Pioneer V-20 0.51 mm 480 min
Nitrile Comasec Comatril 0.55 mm 480 min
Neoprene Edmont-Neox 0.38 mm 480 min
Natural rubber Edmont 36-124 0.46 mm 360 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material at ambient temperatures and protect it
from moisture and oxidizers. If possible, it would be prudent to store this
compound under inert atmosphere.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include restlessness, unsteady
gait, drowsiness, coma, transient stimulation of central nervous system
followed by depression, vomiting, renal damage, anuria and uremia [036].
Other symptoms include lacrimation, general anesthesia, headache, cough,
respiratory stimulation, nausea and pulmonary and liver damage [043]. It
may cause congestion, edema and damage to the brain, acidosis, focal hemor-
rhagic necrosis of the renal cortex, hydropic degeneration of the liver and
kidneys, calcium oxalate crystals in the brain, spinal cord and kidneys;
narcosis, cyanosis, tachypnea, pulmonary edema, muscle tenderness, stupor,
prostration, unconsciousness with convulsions, hypoglycemia, death from
respiratory failure, hypocalcemic tetany, intravascular hemolysis, oliguria,
nystagmus, lymphocytosis, reduced blood pH or glucose, methemoglobinemia and
hyperkalemia [301]. It may also cause low-grade fever, depressed reflexes,
generalized or focal seizures, tetanic contractions, myoclonic jerks, ophthal-
moplegia, papilledema, optic atrophy, tachycardia, mild hypotension, broncho-
pneumonia, cardiac enlargement and congestive failure [430]. Exposure may
lead to anorexia, hematopoietic dysfunction and depression followed by res-
piratory and cardiac failure [346]. It may also lead to blood or central
nervous system damage, eye irritation, dizziness, abdominal pain and discom-
fort, malaise, lumbar pain, loss of appetite and neural dysfunction [058].
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