NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000231
CAS NUMBER: 106-92-3
BASE CHEMICAL NAME: ALLYLGLYCIDYLETHER
PRIMARY NAME: ALLYL GLYCIDYL ETHER
CHEMICAL FORMULA: C6H10O2
STRUCTURAL FORMULA: Not printable
WLN: T3OTJ B1O2U1
SYNONYMS:
((2-PROPENYLOXY)METHYL)OXIRANE
ALLYL 2,3-EPOXYPROPYL ETHER
1-(ALLYLOXY)-2,3-EPOXYPROPANE
1-ALLYL-2,3-EPOXYPROPANE
AGE
NCI-C56666
ETHER, ALLYL 2,3-EPOXYPROPYL
UN2219
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear, colorless liquid
REPOSITORY: Clear, colorless liquid
MOLECULAR WEIGHT: 114.14
SPECIFIC GRAVITY: 0.969 @ 20/4 C [055]
DENSITY: 0.962 g/mL [205,269,275]
MP (DEG C): -100 C [043,055,062,421]
BP (DEG C): 154 C [269,275,346,421]
SOLUBILITIES:
WATER : >=100 mg/mL @ 18.5 C (RAD)
DMSO : >=100 mg/mL @ 18.5 C (RAD)
95% ETHANOL : >=100 mg/mL @ 18.5 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 18.5 C (RAD)
TOLUENE : Miscible
OTHER SOLVENTS: Not available
VOLATILITY:
Vapor pressure: 3.6 mm Hg @ 20 C; 5.8 mm Hg @ 30 C [055]
Vapor density : 3.94 [043,055]
FLAMMABILITY(FLASH POINT):
The flash point of this compound is 57 C (135 F) [058,205,269,275]. It
is combustible. Fires involving this compound can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with acids, bases and oxidizing agents
[058,269].
STABILITY:
This compound may be sensitive to heat [058]. NMR stability screening
indicates that solutions of this compound in water should be stable for at
least 24 hours (RAD).
OTHER PHYSICAL DATA:
Strong odor [058,346]
Refractive index: 1.4332 @ 20 C [047,205,269,275]
Vapor pressure: 4.7 mm Hg @ 25 C [062,421]; 21.59 mm Hg @ 60 C [043]
0% Volatile by volume [058]
TOXICITY
NIOSH REGISTRY NUMBER: RR0875000
TOXICITY:
typ. dose mode specie amount units other
LC50 ihl rat 860 ppm/4H
LD50 orl mus 390 mg/kg
LC50 ihl mus 270 ppm/4H
LD50 skn rbt 2550 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion. Moderately toxic by inhalation and skin contact.
Mutagenic data. A severe skin and eye irritant.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies (Inhalation): Equivocal Evidence: Male Rat
and Female Mouse [620]
NTP Carcinogenesis Studies (Inhalation): No Evidence: Female Rat [620]
NTP Carcinogenesis Studies (Inhalation): Some Evidence: Male Mouse
[620]
MUTATION DATA:
test lowest dose | test lowest dose
---------- ------------------ | ---------- -----------------
mmo-sat 10 mg/plate | mma-sat 10 mg/plate
mmo-esc 20 umol/L | dnd-esc 1 umol/L
mmo-klp 500 umol/L | sln-dmg-orl 5500 ppm
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: Ceiling limit 10 ppm [015,327,545,610]
Final Limit: PEL-TWA 5 ppm; STEL 10 ppm [015,545,610]
ACGIH: TLV-TWA 5 ppm (skin); STEL 10 ppm [015,415,421,610]
NIOSH Criteria Document: Recommended exposure limit of this compound-air:
Ceiling limit 45 mg/m3/15M [015]
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 485 mg/3D MOD
skn-rbt 2 mg/24H SEV
eye-rbt 750 ug/24H SEV
eye-rbt 97 mg SEV
Standards and Regulations: DOT-IMO: Flammable or Combustible Liquid; Label:
Flammable Liquid
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Test Submission (TSCATS) Data Base, January 1989
NIOSH Current Intelligence Bulletin 29, 1978
Meets criteria for proposed OSHA Medical Records Rule
IDLH value: 270 ppm [346]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Allyl glycidyl ether
UN/ID NUMBER: UN2219
HAZARD CLASS: 3 SUBSIDIARY RISK: 6.1 PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
This compound is a component of epoxy resin systems, resin intermediate
and stabilizer of chlorinated compounds, vinyl resins and rubber.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is corrosive [269,275]. It is extremely destructive to
tissues of the mucous membranes and upper respiratory tract, eyes and skin
[269]. It may cause eye, nose and pulmonary irritation [346]. When heated to
decomposition it emits toxic fumes of carbon monoxide and carbon dioxide [058].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl Rubber North B-161 0.40 mm 360 min
Neoprene Edmont NEOX 0.38 mm 240 min
Nitrile North LA-102G 0.20 mm 240 min
PE/EVAL/PE Safety 4 4H 0.07 mm 240 min
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
positive pressure supplied-air respirator or a self-contained breathing
apparatus (SCBA). [651]
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures, and keep
it away from oxidizing materials. STORE AWAY FROM ALL SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include central nervous system
depression and pulmonary edema [043]. It may cause dermatitis, narcosis,
edema and eye, nose and pulmonary irritation [346]. It may also cause spasms,
inflammation and edema of the larynx and bronchi; chemical pneumonitis, burning
sensation, coughing, wheezing, laryngitis, shortness of breath, headache,
nausea and vomiting [269]. Sensitization of the skin and eyes may occur [058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. RR0875000.
April 28, 1989.
[036] Bretherick, L., Ed. Hazards in the Chemical Laboratory. 4th Ed.
The Royal Society of Chemistry. London. 1986. p. 165.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
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[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 56, #A00959.
[052] Midwest Research Institute. MRI Report for Allyl glycidyl ether.
Kansas City, MO. November 5, 1982.
[055] Verschueren, K. Handbook of Environmental Data on Organic
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p. 179.
[058] Information Handling Services. Material Safety Data Sheets
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#1841-006, A-01.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
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[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
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[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
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[107] Occupational Health Services, Inc. Hazardline. Occupational
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[110] Oak Ridge National Laboratory. Environmental Mutagen Information
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[120] Oak Ridge National Laboratory. Environmental Teratogen Information
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[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
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[415] American Conference of Governmental Industrial Hygienists.
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for 1988-1989. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1988. p. 10.
[421] American Conference of Governmental Industrial Hygienists.
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American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 20.
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[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
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