NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 002049
CAS NUMBER: 106-65-0
BASE CHEMICAL NAME: DIMETHYLSUCCINATE
PRIMARY NAME: DIMETHYL SUCCINATE
CHEMICAL FORMULA: C6H10O4
STRUCTURAL FORMULA: CH3OCOCH2CH2COOCH3
WLN: Not available
SYNONYMS:
BUTANEDIOIC ACID, DIMETHYL ESTER
SUCCINIC ACID, DIMETHYL ESTER
METHYL SUCCINATE
DIMETHYL BUTANEDIOATE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless liquid
REPOSITORY: Clear, pale yellow liquid
MOLECULAR WEIGHT: 146.14
SPECIFIC GRAVITY: 1.1198 @ 20/4 C [016,047]
DENSITY: 1.121 @ 20 C [058]
MP (DEG C): 19.5 C [031,205]
BP (DEG C): 196.4 C [016,047]
SOLUBILITIES:
WATER : >=100 mg/mL @ 23 C (RAD)
DMSO : >=100 mg/mL @ 23 C (RAD)
95% ETHANOL : >=100 mg/mL @ 23 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 23 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ether: Soluble [016,047]
Alcohol: Soluble [016,031,047,205]
VOLATILITY:
Vapor pressure: 0.3 mm Hg @ 20 C [058]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 85 C (185 F) [205,269,275]. It is
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used. The autoignition temperature for this compound is 365 C (689 F). Vapor
forms explosive mixtures with air [058].
UEL: 8.5% [058] LEL: 1.0% [058]
REACTIVITY:
This compound is incompatible with acids, bases, oxidizing and reducing
agents [269].
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions of
this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24
hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Refractive Index: 1.4190 @ 20 C [205,269,275]
Boiling point: 80 C @ 11 mm Hg [016,047]; 103.5 C @ 25 mm Hg, 195.3 C @
760 mm Hg [031]
Specific gravity: 1.1202 @ 18/4 C [031]
Sweet odor [058]
100% volatile by weight [058]
Evaporation rate (butyl acetate = 1): <0.1 [058]
TOXICITY
NIOSH REGISTRY NUMBER: Not available
TOXICITY:
typ. dose mode specie amount units other
Not available
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Not available
CARCINOGENICITY: Not available
MUTATION DATA: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA: Not available
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This type of compound is used in the manufacture of lacquers, dyes, esters
for perfumes and succinates and in photography.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may be harmful by inhalation, ingestion or skin absorption
[269]. When heated to decomposition it emits toxic fumes of carbon monoxide
and carbon dioxide [058,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES Expert System Recommended Gloves For Use With Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES expert system was used to extrapolate permeation test
information from compounds in the same chemical class and the following
recommendation(s) are provided. The GlovES system uses permeation data from
literature sources; therefore, extra safety margins should be used with the
recommended exposure times. If this chemical comes into contact with your
glove, or if a tear, puncture or hole develops, remove them at once.
Suggested Glove Type Model Number Thickness Estimated Breakthrough
Butyl rubber North B-174 0.63 mm 480 min
PE/EVOH/PE Broste 4H Glove 0.07 mm 240 min
PVA Edmont 25-545 0.33 mm 360 min
Polylaminate North Silvershield 0.10 mm 360 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under ambient temperatures,
and keep it away from oxidizing materials.
SPILLS AND LEAKAGE:
If you spill this chemical, use absorbent paper to pick up all liquid
spill material. Seal the absorbent paper, as well as any of your clothing
which may be contaminated, in a vapor-tight plastic bag for eventual disposal.
Wash any surfaces you may have contaminated with a soap and water solution.
Do not reenter the contaminated area until the Safety Officer (or other
responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include eye irritation [058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Not listed.
January 16, 1990.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-500, #13,558.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 1271, #8743.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
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[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. December 1989/
January 1990. #2263-022, D-03.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
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Washington, D.C. January 1986. Not listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-358, #d1179.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 802, #B.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 624, #11,275-5.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Not listed.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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