NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000012
CAS NUMBER: 106-46-7
BASE CHEMICAL NAME: DICHLOROBENZENE,1,4-
PRIMARY NAME: 1,4-DICHLOROBENZENE
CHEMICAL FORMULA: C6H4Cl2
STRUCTURAL FORMULA: C6H4Cl2
WLN: GR DG
SYNONYMS:
P-DICHLOROBENZENE
PARA-DICHLOROBENZENE
P-CHLOROPHENYL CHLORIDE
P-DICHLOROBENZOL
PARADICHLOROBENZENE
PARADICHLOROBENZOL
DI-CHLORICIDE
EVOLA
GLOBOL
NCI-C54955
PARACIDE
PARA CRYSTALS
PARADI
PARADOW
PARAMOTH
PARANUGGETS
PARAZENE
PDB
PDCB
PERSIA-PERAZOL
RCRA WASTE NUMBER U070
RCRA WASTE NUMBER U071
RCRA WASTE NUMBER U072
SANTOCHLOR
UN 1592
BENZENE, P-DICHLORO-
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless or white, volatile crystals
REPOSITORY: White crystals
MOLECULAR WEIGHT: 147.00
SPECIFIC GRAVITY: 1.2475 @ 20/4 C [017,047,395]
DENSITY: 1.2417 g/mL @ 60 C [205]
MP (DEG C): 53 C [036,058,205,451]
BP (DEG C): 174 C [017,058,395,451]
SOLUBILITIES:
WATER : <1 mg/mL @ 23 C (RAD)
DMSO : >=100 mg/mL @ 23 C (RAD)
95% ETHANOL : >=100 mg/mL @ 23 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 23 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [017,033,205,430]
Ether: Soluble [017,033,205,395]
Benzene: Soluble [017,033,205,395]
Carbon disulfide: Soluble [033,051,205,395]
Chloroform: Soluble [033,051,205,395]
Most organic solvents: Soluble [173,295]
VOLATILITY:
Vapor pressure: 0.6 mm Hg @ 20 C [055]; 1.8 mm Hg @ 30 C [055,395]
Vapor density : 5.08 [043,051,058,071]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 65.5 C (150 F) [033,043,062,451].
It is combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher. A water spray may
also be used [043,058,371,451].
UEL: Not available LEL: 2.5% [051,071,102]
REACTIVITY:
This chemical is incompatible with oxidizing agents [043,051,058,269].
It is also incompatible with aluminum and its alloys [269]. It liquifies
when mixed with camphor, phenol and salol [295]. It will attack some forms
of plastics, rubber and coatings [102].
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions
of this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Readily sublimes [033,051,062,071]
Specific gravity: 1.4581 @ 20.5/4 C [043,058]
Density: 1.458 g/mL @ 21 C [051]
Boiling point: 55 C @ 10 mm Hg [017,047]
Vapor pressure: 1 mm Hg @ 25 C [173]; 10 mm Hg @ 54.8 C [038,043,058]
Vapor pressure: 20 mm Hg @ 69.2 C; 40 mm Hg @ 84.8 C; 60 mm Hg @ 95.2 C [038]
Vapor pressure: 100 mm Hg @ 108.4 C [038]
Refractive index: 1.5285 @ 60 C [017,033,205]
Aromatic, mothball-like odor [051,071]
Odor threshold: 15-30 ppm [051,071,102,371]
log P octanol: 3.39 @ 20 C [055]
Lambda max (in ethanol): 258 nm, 266 nm, 273 nm, 280 nm [395]
Dielectric constant: 2.41 @ 50 C [051]
Surface tension: 31.4 dynes/cm @ 60 C; 27.2 dynes/cm @ 100 C [051]
Heat of fusion: 29.07 cal/g [051,371]
Sinks in water [371]
Burning rate: ~1.3 mm/min [371]
TOXICITY
NIOSH REGISTRY NUMBER: CZ4550000
TOXICITY:
typ. dose mode specie amount units other
LD50 ipr rat 2562 mg/kg
LDLo orl gpg 2800 mg/kg
TDLo orl hmn 300 mg/kg
LDLo orl hmn 857 mg/kg
LD50 orl mus 2950 mg/kg
LD50 orl rat 500 mg/kg
LD50 scu mus 5145 mg/kg
LDLo unr hmn 357 mg/kg
LDLo unr man 221 mg/kg
LD50 ipr mus 2 gm/kg
LD50 orl rbt 2830 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: A human poison by an unspecified route. Moderately toxic to humans by
ingestion. Moderately toxic experimentally by ingestion, subcutaneous
and intraperitoneal routes. Mildly toxic by subcutaneous route. An
experimental carcinogen and teratogen. Other experimental reproductive
effects. Human systemic effects by ingestion. A human eye irritant.
Mutagenic data. A priority pollutant.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 155 gm/kg/2Y-I
TDLo: orl-mus 155 gm/kg/2Y-I
Review: IARC Cancer Review: Human Inadequate Evidence
IARC Cancer Review: Animal Sufficient Evidence
IARC possible human carcinogen (Group 2B) [015,395,610]
Status: NTP Carcinogenesis Studies (Gavage); Clear Evidence: Male Rat, Male
and Female Mouse [620]
NTP Carcinogenesis Studies (Gavage); No Evidence: Female Rat [620]
NTP Fifth Annual Report on Carcinogens, 1989: anticipated to be
carcinogen [015,610]
MUTATION DATA: See RTECS printout for most current data
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-asn 200 mg/L | spm-rat-ipr 800 mg/kg
mnt-mus-ipr 355 mg/kg/24H |
TERATOGENICITY: See RTECS printout for most current data
Reproductive Effects Data:
TCLo: ihl-rbt 800 ppm/6H (6-18D preg)
TDLo: orl-rat 7500 mg/kg (6-15D preg)
TDLo: orl-rat 10 gm/kg (6-15D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 75 ppm [015,327,545,610]
Final Limit: PEL-TWA 75 ppm; STEL 110 ppm [015,545,610]
ACGIH: TLV-TWA 75 ppm; STEL 110 ppm [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 2
Reactivity (R): 0
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-hmn 80 ppm
Review: Toxicology Review
Standards and Regulations: DOT-Hazard: ORM-A; Label: None
DOT-IMO: Poison B; Label: St. Andrews Cross
Status: EPA TSCA Chemical Inventory, 1989
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Test Submission (TSCATS) Data Base, April 1990
NIOSH Analytical Methods: see Hydrocarbons, halogenated, 1003
IDLH value: 1000 ppm [051,371]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): p-Dichlorobenzene
UN/ID NUMBER: UN1592
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
This compound is used as a moth repellant, general insecticide, pesticide,
fumigant, germicide, miticide, space odorant, air deodorant, chemical inter-
mediate for dyes and organic chemicals, mildew control agent, disintegrating
paste for molding concrete and stoneware, lubricant and disinfectant. It is
used in the manufacture of 2,5-dichloroaniline, pharmaceutical manufacture,
agriculture (to fumigate soil), manufacture of polyphenylene sulfide resins
(used for surface coatings and molding resins) and organic synthesis.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS: Not available
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Neoprene Edmont Neox 1.50 mm 120 min
Nitrile Pioneer A-14 0.50 mm 120 min
Viton North F-121 0.31 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical at ambient temperatures, and keep it
away from all oxidizing materials.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the skin,
eyes and throat [033,051,058,151]. Irritation of the nose may occur [036,
058,102,295]. Irritation of the mucous membranes and lungs may also occur
[301]. Other symptoms of exposure include weakness, dizziness, weight loss
and liver injury [033]. Exposure may lead to drowsiness, allergic purpura,
acute glomerulonephritis, dermatitis and lens opacities [295]. It may also
lead to hemolytic anemia, liver necrosis, headaches, periorbital swelling
and profuse rhinitis [346]. It can cause anorexia, nausea, vomiting, jaun-
dice and cirrhosis [051,071,346]. Allergic skin reactions and damage to the
liver and kidneys occur [269]. Unspecified changes may occur in the eyes,
lungs, thorax and respiratory system [043]. Other symptoms of exposure are
hypersensitivity, oliguria, refractory anemia, dyspnea, petechial and purpuric
rash, swollen hands and feet, cataracts, coughing, hypochromic anemia, granulo-
cytopenia, aplastic anemia, congestive heart failure, nephrosis, inflammation
of the mucosa, methemoglobinemia, leukemia, myeloblastic leukemia, myelo-
proliferative syndrome and death [173]. Central nervous system effects have
been reported [301]. Pulmonary granulocytosis has also been reported [395].
Hepatic enlargement may occur [099]. It may cause pain to the eyes and nose,
swelling and inflammation of the nose [051 071]. It may also cause irritation
of the upper respiratory tract, a slight burning sensation and red blotching
of the skin due to allergic reactions [058]. Vertigo may result from exposure
[421]. Other symptoms may include asthenia, hypogranulocytosis, hyperleuko-
cytosis, numbness, clumsiness, ascites, elevated serum bilirubin and elevated
alkaline phosphatase [430].
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