NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000985
CAS NUMBER: 105-60-2
BASE CHEMICAL NAME: CAPROLACTAM
PRIMARY NAME: CAPROLACTAM
CHEMICAL FORMULA: C6H11NO
STRUCTURAL FORMULA: Not printable
WLN: T7MVTJ
SYNONYMS:
AMINOCAPROIC LACTAM
6-AMINOCAPROIC ACID LACTAM
6-AMINOHEXANOIC ACID CYCLIC LACTAM
2-AZACYCLOHEPTANONE
6-CAPROLACTAM
GAMMA-CAPROLACTAM
6-HEXANELACTAM
HEXANOLACTAM
HEXAHYDRO-2H-AZEPIN-2-ONE (9CI)
HEXAHYDRO-2-AZEPINONE
HEXANOIC ACID-6-AMINO-,LACTAM
2-PERHYDROAZEPINONE
2H-AZEPIN-7-ONE,HEXAHYDRO
EPSILON-CAPROLACTAM
CYCLOHEXANONE ISO-OXIME
2-OXOHEXAMETHYLENIMINE
HEXANNIC ACID
1,6-HEXOLACTAM
2-KETOHEXAMETHYLENIMINE
2-OXOHEXAMETHYLENIMINE
6-AMINOCAPROIC ACID LACTAM
OMEGA-CAPROLACTUM
HEXANONE ISOXIME
2H-AZEPIN-2-ONE,HEXAHYDRO
HEXAMETHYLENIMINE,2-OXO-
E-CAPROLACTUM
NCI-C50646
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White crystalline solid
REPOSITORY: White crystalline solid
MOLECULAR WEIGHT: 113.16
SPECIFIC GRAVITY: 1.02 @ 75/4 C [031,205,421]
DENSITY: Not available
MP (DEG C): 69 C [043,346]
BP (DEG C): 266.9 C @ 760 mm Hg [395]
SOLUBILITIES:
WATER : >=100 mg/mL @ 20.5 C (RAD)
DMSO : >=100 mg/mL @ 20.5 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20.5 C (RAD)
METHANOL : Freely soluble [031]
ACETONE : >=100 mg/mL @ 20.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Cyclohexane: <1 mg/mL @ 21 C (RAD)
Chloroform: Soluble [017,395]
Chlorinated solvents: Soluble [031,062,395]
Petroleum distillates: Soluble [031,051,062,395]
Tetrahydrofurfuryl alcohol: Freely soluble [031]
Dimethyl formamide: Freely soluble [031,395]
Ether: Freely soluble [031]
Benzene: Soluble [017,395]
Cychlohexene: Soluble [031,051,062,395]
VOLATILITY:
Vapor pressure: 0.001 mm Hg @ 20 C [055,395]; 3 mm Hg @ 100 C [062]
Vapor density : 3.91 [055,395]
FLAMMABILITY(FLASH POINT):
The flash point for this chemical is 125 C (257 F) [031,421]. It is
combustible. Fires involving this compound should be controlled using a dry
chemical, carbon dioxide or Halon extinguisher. The autoignition temperature
for this compound is 375 C (707 F) [107].
UEL: 8% [107] LEL: 1.4% [107]
REACTIVITY:
This compound can react with strong oxidizing agents and strong bases
[269]. It can also react with chlorinated hydrocarbons and nitro compounds
[107]. A potentially explosive reaction occurs with acetic acid + dinitrogen
trioxide [043].
STABILITY:
This compound is hygroscopic [031,036,269,421]. Solutions of this
chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours
under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Boiling point: 100 C @ 3 mm Hg [421]
139 C @ 12 mm Hg [017,026,055]
180 C @ 50 mm Hg [062,205]
Refractive index: 1.4965 @ 31 C; 1.4935 @ 40 C [062]
Density: 1.05 g/mL @ 25/4 C (70% aqueous soln.) [031,062]
TOXICITY
NIOSH REGISTRY NUMBER: CM3675000
TOXICITY:
typ. dose mode specie amount units other
TCLo ihl hmn 100 ppm
LD50 orl rat 1210 mg/kg
LDLo ipr rat 900 mg/kg
LD50 scu mus 750 mg/kg
LD50 skn rbt 1438 mg/kg
LDLo scu frg 2800 mg/kg
LD50 ipr mus 650 mg/kg
LC50 ihl rat 300 mg/m3/2H
LD50 orl mus 930 mg/kg
LD50 ivn mus 480 mg/kg
LC50 ihl mus 450 mg/m3
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Moderately toxic by ingestion, skin contact, intraperitoneal and
subcutaneous routes. Human systemic effects by inhalation.
Experimental reproductive effects. Human mutagenic data. A skin and
eye irritant.
CARCINOGENICITY:
Review: IARC Cancer Review: Animal Evidence suggests lack of carcinogenicity
IARC: Probably not a human carcinogen (Group 4) [015,610]
Status: NTP Carcinogenesis Bioassay (Feed); Negative: Male and Female Rat,
Male and Female Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ------------ -----------------
spm-rat-ihl 125 mg/m3/10W | bfa-rat/ovr 76 mg/kg
cyt-ham:lng 8 gm/L | cyt-hmn:lym 270 mg/L
mrc-smc 400 mg/L | mmo-smc 100 mg/L
mma-smc 100 mg/L | otr-mus:emb 2500 mg/L
slt-dmg-orl 5 mmol/L | dni-hmn:fbr 1 mmol/L
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 10 gm/kg (6-15D preg)
TCLo: ihl-rat 125 mg/m3/24H (76D male)
TDLo: orl-rbt 3450 mg/kg (6-28D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register Subpart Z
Final Limit: PEL-TWA 1 mg/m3; STEL 3 mg/m3 (dust) [015,545,610]
PEL-TWA 5 ppm; STEL 10 ppm (vapor) [015,545,610]
ACGIH: TLV-TWA 1 mg/m3; STEL 3 mg/m3 with a notice of intent to delete STEL
(dust) [415,421,610]
TLV-TWA 4.3 ppm; STEL 8.6 ppm with a notice of intent to change to
a TWA of 5 ppm and to delete STEL (vapor) [415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rbt 20 mg/24H MOD
skn-rbt 500 mg/24H MLD
Status: EPA TSCA Chemical Inventory, 1986
EPA Genetox Program 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Test Submission (TSCATS) Data Base, January 1989
EPA Genetox Program 1988, Negative: CHO gene mutation
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances, n.o.s.
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
This compound is used in the manufacture of synthetic fibers, plastics,
bristles, film, coatings, synthetic leather, plasticizers and paint vehicles.
It is a cross-linking agent for polyurethanes and it is used in the synthesis
of lysine.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may cause irritation of the skin, eyes, upper respiratory
tract and mucous membranes. When heated to decomposition it emits toxic
fumes of CO, CO2 and NOx [269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-174 0.66 mm 480 min
PVA Edmont 25-545 Unknown 360 min
Viton North F-091 0.25 mm 480 min
Nitrile Edmont 37-155 0.38 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from moisture. If possible, it would be prudent to
store this compound under inert atmosphere.
SPILLS AND LEAKAGE:
If you spill this chemical, then you should dampen the solid spill
material with water and transfer the dampened material to a suitable container.
Use absorbent paper dampened with water to pick up any remaining material.
Seal your contaminated clothing and the absorbent paper in a vapor-tight
plastic bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include eye irritation, visual
disturbance, cough, respiratory distress, dry throat, nausea, dyspnea,
eczema, erythema, dermatitis, skin sensitization, skin burns and vomiting
[107]. It may also cause contact dermatitis, eczema of the hands and light
sensitivity [346]. It may also have central nervous system effects [301].
SOURCES
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