NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001960
CAS NUMBER: 104-55-2
BASE CHEMICAL NAME: CINNAMALDEHYDE
PRIMARY NAME: CINNAMALDEHYDE
CHEMICAL FORMULA: C9H8O
STRUCTURAL FORMULA:
WLN: VH1U1R
SYNONYMS:
2-PROPENAL, 3-PHENYL-
CASSIA ALDEHYDE
CINNAMAL
CINNAMIC ALDEHYDE
PHENYLACROLEIN
3-PHENYLPROPENAL
3-PHENYL-2-PROPENAL
CINNAMYL ALDEHYDE
3-PHENYLACROLEIN
BENZYLIDENEACETALDEHYDE
3-PHENYL-2-PROPENALDEHYDE
ZIMTALDEHYDE
3-PHENYLACRYALDEHYDE
NCI-C56111
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Yellow oily liquid
REPOSITORY: Not available
MOLECULAR WEIGHT: 132.15
SPECIFIC GRAVITY: 1.112 @ 15/4 C
DENSITY: Not available
MP (DEG C): -7.5
BP (DEG C): 251 C
SOLUBILITIES:
WATER : Slightly soluble
DMSO : Not available
95% ETHANOL : Soluble
METHANOL : Not available
ACETONE : Not available
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Miscible
Oils: Miscible
ETHER : Miscible
VOLATILITY:
Vapor pressure: 1 mm @ 76.1 C; 40 mm @ 152 C
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 71 C ( 160 F). It is combustible.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This compound reacts with sodium hydroxide.
STABILITY:
This chemical may be unstable to prolonged exposure to air.
OTHER PHYSICAL DATA:
Cinnamon odor
Sweet taste
Thickens upon exposure to air
Index of refraction: 1.618-1.623 @ 20 C
log Poct: 1.88
TOXICITY
NIOSH REGISTRY NUMBER: GD6475000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 2220 mg/kg
LD50 orl mus 2225 mg/kg
LD50 ipr mus 610 mg/kg
LD50 ivn mus 75 mg/kg
LDLo par mus 200 mg/kg
LD50 orl gpg 1160 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: HIGH via intraperitoneal, MODERATE via oral and inhalation routes
CARCINOGENICITY:
Tumorigenic Data:
TDLo: ipr-mus 800 mg/kg/8W-I
Status: NTP Carcinogenesis Studies; on test, April 1985
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mma-sat 500 ug/plate | dni-mus:leu 31500 ug/L
oms-mus:leu 31500 ug/L | cyt-ham:fbr 15 mg/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-hmn 40 mg/48H SEV
Review: Toxicology Review
Status: Reported in EPA TSCA Inventory, 1983
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
Used in flavors and perfumes
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
Exposure to this chemical may cause irritation of the skin, eyes, upper
respiratory tract and mucous membranes.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container
under an inert atmosphere, and store it at refrigerated temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
Not available
OTHER: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include inflammation and erosion
of gastrointestinal muscous.
SOURCES
SOURCES:
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. GD6475000.
Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 65th Ed. CRC Press, Inc. Boca Raton,
FL. 1984. p. C-233; #5070.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 5, p. 4664; #P-01511.
Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 326; #2271.
Bretherick, L., Ed. Hazards in the Chemical Laboratory. 3rd Ed.
The Royal Society of Chemistry. London. 1981. p. 255.
Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 528.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
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Verschueren, K. Handbook of Environmental Data on Organic
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Van Nostrand Reinhold. New York. 1981. p. 253.
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Butterworths. London. 1984. p. 674.
U.S. Environmental Protection Agency, Office of Toxic Substances.
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of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-256; #860.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
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[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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