NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000112
CAS NUMBER: 103-90-2
BASE CHEMICAL NAME: HYDROXYACETANILIDE,4-
PRIMARY NAME: 4-HYDROXYACETANILIDE
CHEMICAL FORMULA: C8H9NO2
STRUCTURAL FORMULA: CH3CONHC6H4OH
WLN: QR DMV1
SYNONYMS:
ACETAMINOPHEN
4'-HYDROXYACETANILIDE
N-(P-HYDROXYPHENYL)ACETAMIDE
N-(4-HYDROXYPHENYL)ACETAMIDE
P-ACETAMIDOPHENOL
PARACETAMOL
4-ACETAMIDOPHENOL
P-ACETAMINOPHENOL
N-ACETYL-P-AMINOPHENOL
P-ACETYLAMINOPHENOL
P-HYDROXYACETANILIDE
ACETANILIDE, 4'-HYDROXY-
ACETAMIDE, N-(P-HYDROXYPHENYL)-
ACETAMIDE, N-(4-HYDROXYPHENYL)-
PHENOL, P-ACETAMIDO-
ABENSANIL
ACAMOL
ACETAGESIC
ACETALGIN
ACETAMINOFEN
ALGOTROPYL
ALPINYL
ALVEDON
AMADIL
ANAFLON
ANELIX
ANHIBA
APADON
APAMID
APAMIDE
APAP
BEN-U-RON
BICKIE-MOL
CALPOL
CETADOL
CLIXODYNE
DATRIL
DIAL-A-GESIC
DIROX
DOLIPRANE
DYMADON
ENELFA
ENERIL
EXDOL
FEBRILIX
FEBRO-GESIC
FEBROLIN
FENDON
FINIMAL
G 1
GELOCATIL
HEDEX
HOMOOLAN
JANUPAP
KORUM
LESTEMP
LIQUAGESIC
LONARID
LYTECA
LYTECA SYRUP
MOMENTUM
MULTIN
NAPA
NAPAFEN
NAPAP
NAPRINOL
NCI-C55801
NOBEDON
PACEMO
PANADOL
PANETS
PANEX
PANOFEN
PARACETAMOLE
PARACETANOL
PARAPAN
PARASPEN
PARMOL
PEDRIC
PHENDON
PYRINAZINE
SK-APAP
TABALGIN
TAPAR
TEMLO
TEMPANAL
TEMPRA
TRALGON
TUSSAPAP
TYLENOL
VALADOL
VALGESIC
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White crystalline powder
REPOSITORY: White crystals
MOLECULAR WEIGHT: 151.16
SPECIFIC GRAVITY: 1.293 @ 21/4 C [033,047,062,205]
DENSITY: Not available
MP (DEG C): 169-172 C [269,275,365]
BP (DEG C): Not available
SOLUBILITIES:
WATER : 1-5 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : 1 in 10 [315]
ACETONE : 50-100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Water (boiling): 1 g/20 mL [295,365]
Dimethylformamide: Soluble [033]
Ethylene dichloride: Soluble [033]
Ethyl acetate: Soluble [033,051]
Petroleum ether: Practically insoluble [033,051]
Pentane: Practically insoluble [033,051]
Ether: Insoluble [295,315,365]
Benzene: Insoluble [033,051,365]
Alcohol: 1 g/7 mL [365]
Chloroform: 1 g/50 mL [365]
Glycerin: 1 g/40 mL [295,365]
Propylene glycol: 1 g/9 mL [295,365]
Solutions of alkali hydroxides: Soluble [295,315,365,455]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY (FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher. A water spray may
also be used [058,269].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizers [058,269].
STABILITY:
This chemical is sensitive to light [052,295,455]. In the presence of
heat and water, it will hydrolyze [058]. It is very stable in aqueous solu-
tion. Its pH-rate profile reveals specific acid and specific base catalysis
with the maximum stability in the pH range 5 to 7 [295,365]. Solutions of
this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24
hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Odorless [062,295,315,365]
Bitter taste [062,295,365,455]
pH of saturated aqueous solution: ~6 [315,365]
pKa: 9.5 @ 20 C [455]
UV max (in 0.1N hydrochloric acid): 245 nm (E = 661) [455]
UV max (in 0.1N sodium hydroxide): 257 nm (E = 715) [455]
UV max (in 95% ethanol): 292 nm, 249 nm (epsilon = 1854, 13349) [052]
TOXICITY
NIOSH REGISTRY NUMBER: AE4200000
TOXICITY:
typ. dose mode specie amount units other
LDLo orl chd 360 mg/kg/2D
TDLo orl chd 801 mg/kg
TDLo orl wmn 160 mg/kg
TDLo orl wmn 490 mg/kg
LDLo orl hmn 357 mg/kg
LDLo orl wmn 260 mg/kg
LDLo orl man 714 mg/kg
TDLo orl inf 1440 mg/kg/6D
LDLo orl hmn 143 mg/kg
TDLo orl man 77 mg/kg
LD50 orl rat 2404 mg/kg
LD50 ipr rat 1205 mg/kg
LD50 orl mus 338 mg/kg
LD50 ipr mus 367 mg/kg
LD50 scu mus 310 mg/kg
LDLo ivn dog 826 mg/kg
LD50 orl gpg 2620 mg/kg
LDLo scu frg 3030 mg/kg
LD50 unr mam 891 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: A human poison by ingestion and possibly other routes. An experimental
poison by intraperitoneal route. Moderately toxic by subcutaneous,
intravenous and possibly other routes. An experimental carcinogen and
tumorigen. Experimental teratogenic and reproductive effects. Human
mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 164 gm/kg/78W-C
TDLo: orl-mus 135 gm/kg/77W-C
TD : orl-mus 270 gm/kg/77W-C
TD : orl-rat 329 gm/kg/78W-C
Status: NTP Carcinogenesis Studies; on test (two year studies), January 1990
MUTATION DATA: See RTECS printout for most current data
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
oms-hmn:lym 200 mg/L | cyt-hmn:lym 200 mg/L
cyt-hmn-orl 42860 ug/kg | mnt-rat:kdy 10 mmol/L
dns-rat:lvr 10 mmol/L | dns-mus:lvr 7500 umol/L
cyt-mus-orl 50 mg/kg | sln-mus-orl 25 mg/kg
dnd-ham:lng 3 mmol/L | dni-ham:lng 160 umol/L
oms-ham:lng 3 mmol/L | cyt-ham:ovr 70 mg/L/24H
cyt-ham:fbr 60 mg/L | cyt-ham:lng 10 mg/L
sce-ham:ovr 200 mg/L | sce-ham:lng 1 mmol/L
TERATOGENICITY: See RTECS printout for most current data
Reproductive Effects Data:
TDLo: orl-wmn 650 mg/kg (29W preg)
TDLo: orl-rat 1500 mg/kg (8-19D preg)
TDLo: orl-rat 12500 mg/kg (14D pre/1-11D preg)
TDLo: orl-rat 13 gm/kg (14D pre/1-11D preg)
TDLo: orl-rat 35 gm/kg (70D male)
TDLo: orl-mus 25 mg/kg (1D male)
TDLo: orl-mus 600 mg/kg (1D male)
TDLo: orl-mus 2500 mg/kg (6-15D preg)
TDLo: orl-rbt 2 gm/kg (1D pre)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 0
Flammability (F): 1
Reactivity (R): 0
H0: Materials which on exposure under fire conditions would offer no
hazard beyond that of ordinary combustible material (see NFPA for
details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Review: Toxicology Review-4
Status: EPA Genetox Program 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Chemical Inventory, 1989
A potentially toxic dose by mouth in an adult person is 10 grams [058,151].
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as an analgesic and antipyretic. It is used in
the treatment of a wide variety of arthritic and rheumatic conditions involving
musculoskeletal pain, as well as in other painful disorders such as headache,
dysmenorrhea, myalgias and neuralgias. It is also indicated as an analgesic
and antipyretic in diseases accompanied by discomfort and fever, such as the
common cold and other viral infections. Other uses include the manufacture
of azo dyes and photographic chemicals, as an intermediate for pharmaceuticals
and as a stabilizer for hydrogen peroxide.
COMMENTS:
This chemical reacts with aspirin [295,395].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may be harmful by ingestion and inhalation. It may cause
irritation of the skin, eyes, mucous membranes and upper respiratory tract
[269]. When heated to decomposition it emits toxic fumes of carbon monoxide,
carbon dioxide and nitrogen oxides [043,058,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Natural rubber Ansell Canners 392 0.48 mm 240 min
Butyl rubber North B-161 0.41 mm 480 min
PE/EVAL/PE Safety4 4H 0.07 mm 240 min
Butyl rubber/Neoprene Comasec Dipco 0.60 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this material from exposure to light. Keep it away
from oxidizing materials and store it under ambient temperatures.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of overexposure to this compound include nausea, vomiting,
cyanosis from methemoglobinemia, injury to the liver, kidneys, central
nervous system and heart, circulatory collapse, drowsiness, confusion, liver
tenderness, low blood pressure, cardiac arrhythmias, jaundice, acute renal
failure, death due to liver necrosis, metabolic acidosis, hepatic damage
and cirrhosis [301]. Other symptoms include changes in exocrine pancreas,
diarrhea, irritability, somnolence, general anesthesia, fever and hepatitis
[043]. Diaphoresis and general malaise may occur [151,158,164]. Exposure
may lead to hematological reactions and, occasionally, skin rashes and
other allergic reactions [295]. The rash is usually erythematous or urti-
carial, but sometimes it is more serious and may be accompanied by drug
fever and mucosal lesions [406]. Exposure to large amounts may lead to
pallor, anorexia, abdominal pain, abnormalities of glucose metabolism and
hepatic encephalopathy [295]. It may also lead to epigastric pain, sweating,
paresthesias of distal extremities, muscular aching, weakness, dizziness,
central nervous system depression (rare), pain in the upper right quadrant,
enlarged liver, oliguria, anuria, coagulation defects and myocardiopathy
characterized by ST segment abnormalities, T-wave flattening and pericarditis
[151]. This compound can cause purpura, generalized bleeding and hypoglycemia
[455]. It can also cause neutropenia, pancytopenia, leukopenia, thrombocyto-
penia and nephrotoxicity [406]. Other symptoms may include wheezing, general
discomfort, blood changes including many anemias (aplastic anemia), central
nervous system stimulation, swollen tongue, rapid pulse, skin eruptions,
chills, excitement, delirium, vascular collapse and convulsions [058].
Irritation of the skin, eyes, mucous membranes and upper respiratory tract
may occur [269].
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