NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001061
CAS NUMBER: 101-77-9
BASE CHEMICAL NAME: METHYLENEDIANILINE,4,4'-
PRIMARY NAME: 4,4'-METHYLENEDIANILINE
CHEMICAL FORMULA: C13H14N2
STRUCTURAL FORMULA: H2NC6H4CH2C6H4NH2
WLN: ZR D1R DZ
SYNONYMS:
4,4'-DIAMINODIPHENYLMETHANE
BIS(P-AMINOPHENYL)METHANE
BIS(4-AMINOPHENYL)METHANE
DADPM
DAPM
DDM
P,P'-DIAMINODIPHENYLMETHANE
DIANILINOMETHANE
MDA
4,4'-METHYLENEBISANILINE
P,P'-METHYLENEDIANILINE
NCI-C54604
TONOX
4,4'-DIAMINODITAN
4-(4-AMINOBENZYL)ANILINE
ANCAMINE TL
ARALDITE HARDENER 972
4,4'-METHYLENEBISBENZENAMINE
CURITHANE
DIAMINODIPHENYLMETHANE
DI-(4-AMINOPHENYL)METHANE
DIANILINEMETHANE
4,4'-DIPHENYLMETHANEDIAMINE
EPICURE DDM
EPIKURE DDM
HT 972
JEFFAMINE AP-20
METHYLENEBIS(ANILINE)
4,4'-METHYLENEBIS(BENZENEAMINE)
METHYLENEDIANILINE
SUMICURE M
UN 2651
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Tan flakes
REPOSITORY: Tan flakes
MOLECULAR WEIGHT: 198.27
SPECIFIC GRAVITY: Not available
DENSITY: 1.15 g/mL @ 25 C [058]
MP (DEG C): 91.5-92 C [031,346,395,421]
BP (DEG C): 398-399 C @ 768 mm Hg [017,031,047,395]
SOLUBILITIES:
WATER : <1 mg/mL @ 19 C (RAD)
DMSO : >=100 mg/mL @ 19 C (RAD)
95% ETHANOL : >=100 mg/mL @ 19 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 19 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Organic solvents: Soluble [395]
Ether: Very soluble [031,062,205,421]
Benzene: Very soluble [031,062,205,395]
Alcohol: Very soluble [031,062,205,395]
VOLATILITY:
Vapor pressure: 0.0000001 mm Hg @ 25 C (calculated) [058]
Vapor density : 6.8 [395]
FLAMMABILITY(FLASH POINT):
The flash point of this compound is 221 C (430 F) [058,205,269,275]. It
is combustible. Fires involving this material can be controlled using a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be used
[058,451,610].
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with strong oxidizing agents [058,269]. It
is also incompatible with acids. It will catalyze isocyanate-alcohol and epoxy
reactions [058].
STABILITY:
This compound oxidizes in air [395]. It is also light sensitive
especially in solution [052,058,395]. Slow air oxidation is catalyzed by light
(visibly darkens). This chemical may also be somewhat hygroscopic [052,058].
It will polymerize if heated above 125 C [058]. Solutions of this chemical in
water, DMSO, 95% ethanol or acetone should be stable for 24 hours when
protected from air and light (RAD).
OTHER PHYSICAL DATA:
Faint amine odor [043,058,421]
Vapor pressure: 0.1 mm Hg @ 152 C [421]; 1 mm Hg @ 197 C [395]
Boiling point: 257 C @ 18 mm Hg [017,031,047]; 249-253 C @ 15 mm Hg [031]
Boiling point: 232 C @ 9 mm Hg [025,031]
TOXICITY
NIOSH REGISTRY NUMBER: BY5425000
TOXICITY:
typ. dose mode specie amount units other
LDLo orl dog 300 mg/kg
LDLo scu dog 400 mg/kg
TDLo orl man 8420 ug/kg
LD50 ipr rat 193 mg/kg
LD50 scu rat 200 mg/kg
LD50 orl mus 745 mg/kg
LD50 ipr mus 74 mg/kg
LD50 orl rbt 620 mg/kg
LD50 orl gpg 260 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion, subcutaneous and intraperitoneal routes. An
experimental carcinogen and tumorigen. Human systemic effects by
ingestion. An eye irritant. Mutagenic data. It is not rapidly
absorbed through the skin.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 320 mg/kg/I
TDLo: scu-rat 1410 mg/kg/I
Review: IARC Cancer Review: Animal Sufficient Evidence
IARC possible human carcinogen (Group 2B) [610]
Status: ACGIH suspected human carcinogen [610]
NTP anticipated human carcinogen [610]
NTP Fourth Annual Report on Carcinogens, 1984
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-sat 250 ug/plate | dnd-rat-ipr 370 umol/kg
mma-sat 50 ug/plate | sce-mus-ipr 9 mg/kg
dns-rat:lvr 10 umol/L |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: TLV-TWA 0.1 ppm (skin) [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 3
Flammability (F): 1
Reactivity (R): 0
H3: Materials extremely hazardous to health but areas may be entered
with extreme care (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rbt 100 mg/24H MOD
Review: Toxicology Review
Standards and Regulations: DOT-IMO: Poison B; Label: St. Andrews Cross
Status: NIOSH Current Intelligence Bulletin 8, 1976 and Bulletin 47, 1986
EPA TSCA Chemical Inventory, 1986
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Section 8(e) Status Report 8EHQ-1285-0577
EPA TSCA Test Submission (TSCATS) Data Base, January 1989
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): 4,4'-Diaminodiphenyl methane
UN/ID NUMBER: UN2651
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
This compound is used as a curing agent for epoxy resins and urethane
elastomers, as a intermediate in the preparation of polyurethanes and Spandex
fibers, in the determination of tungsten and sulfates and in the preparation
of azo dyes. It is also used as a corrosion inhibitor, cross-linking agent
for epoxy resins, in the preparation of isocyanates and polyisocyanates, in the
rubber industry, as a curative for neoprene, as a anti-frosting agent (anti-
oxidant) in footwear and raw material in preparation of poly(amide-imide)
resins (used in magnet wire enamels).
COMMENTS:
The technical grade of this compound contains 4% 2,4'-Methyleneaniline
[055].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is harmful by inhalation, ingestion or skin contact [036,
058,269]. It may be absorbed through the skin [058,269,346,421]. When heated
to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide,
nitrogen oxides, hydrogen cyanide and aniline [043,058,269]. This compound
may cause irritation to the skin, eyes and respiratory tract [058].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PVA Edmont 25-545 Unknown 480 min.
Unknown North Silvershield 0.10 mm 480 min.
PE/EVOH/PE Safety 4 4H 0.07 mm 240 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container
under an inert atmosphere, and store it at refrigerated temperatures.
Keep it away from oxidizing materials and protect it from light.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Exposure to this compound causes toxic hepatitis [099,275,346,395]. It
is the causative agent in "Epping Jaundice", a condition which includes severe
right-upper-quadrant pain, and high fever and chills, with subsequent jaundice
[031,421,430]. This condition may also result in portal inflammation, eosin-
ophil infiltration, cholangitis and cholestasis [395]. Other symptoms of
exposure to this compound include weakness, abdominal pain, nausea and/or
vomiting and anorexia [031,058]. Inhalation and/or ingestion of the dust leads
to liver damage [036]. Eye contact may cause burning, itching and tearing
[058]. It is painfully irritating to the eyes at 4 ppm [421]. Skin contact
can result in reddening and swelling, as well as skin sensitization causing
allergic dermatitis with rash, itching, hives and swelling of the arms and legs
[058]. Myocardial damage has also been reported [099,395,421]. It is suspect
in the development of choroidal melanoma [099]. It may also cause kidney
damage [301]. Persons with pre-existing skin disorders or impaired pulmonary
function may be more susceptible to the effects of this chemical. Other
symptoms include corneal burns, irritation to the skin, eyes and respiratory
tract, blood and spleen damage and conjunctivitis [058].
SOURCES
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