NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001055
CAS NUMBER: 100-74-3
BASE CHEMICAL NAME: ETHYLMORPHOLINE,N-
PRIMARY NAME: N-ETHYLMORPHOLINE
CHEMICAL FORMULA: C6H13NO
STRUCTURAL FORMULA:
WLN: T6N DOTJ A2
SYNONYMS:
4-ETHYLMORPHOLINE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Colorless liquid
REPOSITORY: Clear, colorless liquid
MOLECULAR WEIGHT: 115.20
SPECIFIC GRAVITY: 0.916 @ 20/20 C
DENSITY:
MP (DEG C): -63 C
BP (DEG C): 138-139 C
SOLUBILITIES:
WATER : >=100 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
ETHER : Soluble
BENZENE: Soluble
VOLATILITY:
Vapor pressure: 6.2 mm Hg @ 20 C
Vapor density : 4.00
FLAMMABILITY(FLASH POINT):
The flash point of this chemical is 27 C (82 F). It is flammable.
Fires involving this material can be controlled with a dry chemical,
carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This material can react vigorously with oxidizing materials. It dissolves
LiAlH4.
STABILITY:
This chemical is sensitive to prolonged exposure to air.
OTHER PHYSICAL DATA:
Weight/gallon: 7.6 pounds @ 20 C
Ammoniacal odor
Refractive index: 1.4415 @ 20 C
Specific gravity: 0.9886 @ 20/4 C
TOXICITY
NIOSH REGISTRY NUMBER: QE4025000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 1780 mg/kg
LD50 orl mus 1200 mg/kg
LC50 ihl mus 18000 mg/m3/2H
LD50 ivn mus 180 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: HIGH via intravenous route. MODERATE via oral route. LOW via inhala-
tion route. A human irritant. A skin and eye irritant.
CARCINOGENICITY: Not available
MUTATION DATA: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 20 ppm (skin) [610]
Final Limit: PEL-TWA 5 ppm (skin) [610]
ACGIH: TLV-TWA 5 ppm (skin) [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 453 mg open MLD
eye-rbt 2 mg open SEV
Status: Reported in EPA TSCA Inventory, 1983
"NIOSH Manual of Analytical Methods" Vol 3 S146
"NIOSH Manual of Analytical Methods" to be revised by June, 1985
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Flammable liquids, n.o.s.
(N-Ethylmorpholine)
UN/ID NUMBER: UN1993
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
Intermediate for dyes, pharmaceuticals, rubber accelerators and emulsifying
agents; solvent for fats, fatty oils, dyes, resins and oils; catalyst in
making polyurethane foams.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This chemical irritates the skin and eyes. It can be absorbed through the
skin. When heated to decomposition it emits toxic fumes.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container
under an inert atmosphere, and store it at refrigerated temperatures.
STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this chemical may include irritation of the skin,
eyes and mucous membranes and visual aberrations.
SOURCES
SOURCES:
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. QE4025000.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 63rd Ed. CRC Press, Inc. Boca Raton, FL.
1982. p. C-378, #9233.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Supplement 2. Chapman and Hall. New York. 1982. Vol 4, p. 328, #M-20236.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 1377.
Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. pp. 660-661.
Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. 1983. Listed.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1984. p. 534, #23,952-6.
American Confernece of Governmental Industrial Hygenists.
Threshold Limit Values for Chemical Substances and
Physical Agents in the Work Environment with Intended
Changes for 1984-85. American Conference of Governmental
Industrial Hygenists. Cincinnati, OH. 1984. p. 19.
Bretherick, L., Ed. Hazards in the Chemical Laboratory. 3rd Ed.
The Royal Society of Chemistry. London. 1981. p. 333.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. pp. 768-769, #477.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Proctor, N.H. and J.P. Hughes. Chemical Hazards of the Workplace.
J.B. Lippincott. Philadelphia. 1978. p. 267.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. pp. 440-441.
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. p. 239, #294.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 35.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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